[Effect of serum from IgA nephropathy patients on IL-1 production from P388 D1 cell lines].
Zhonghua Nei Ke Za Zhi
; 31(1): 15-7, 59, 1992 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-1395905
ABSTRACT
The study was designed to investigate IL-1 production from P388D1 cell using serum from 40 cases with IgA nephropathy (IgAN) as stimulative factor. It was found that there was a relationship between IL-1 and renal morphological change. The result indicated that IL-1 production by P388D1 cell was much higher in the presence of the serum than that in the absence (CPM 47597 +/- 26213 vs 36567 +/- 14377 P less than 0.05). The level of IL-1 correlated obviously to the renal morphologic changes (r = 0.406, P less than 0.05). It is suggested that in the serum of IgAN patients there are certain factors stimulating P388D1 cell to produce IL-1, which may contribute to the pathogenesis of IgAN.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interleucina-1
/
Glomerulonefritis por IGA
/
Riñón
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Año:
1992
Tipo del documento:
Article