Behavioral and neurochemical sequelae in young rats of antenal hypoxia.
Early Hum Dev
; 29(1-3): 83-90, 1992.
Article
en En
| MEDLINE
| ID: mdl-1396282
To test the hypothesis that perinatal hypoxia may have postnatal consequences via à vis learning memory, and neurochemical sequelae, we exposed pregnant Sprague-Dawley rats to 10.5% O2 for 4 h per day (0800-1200 h) or continuously from gestional day E15 to E20. On E20 we quantified ornithine decarboxylase activity and polyamine concentrations in fetal brain. We also conducted behavioral tests from postnatal day P3 to P110. Relatively mild antenatal hypoxia resulted in altered learning, memory, and delayed maturation of early developmental sensorimotor function. These behavioral changes disappeared at various postnatal ages, depending on the function. Perinatal hypoxia also altered the pharmacological response to dopaminergic drugs. In addition, antenatal hypoxia feminized a male nonreproductive sexual behavior, that of saccharin preference. Acute hypoxia also resulted in an increase in the enzyme ornithine decarboxylase and polyamines, which may affect brain development.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ornitina Descarboxilasa
/
Conducta Animal
/
Poliaminas Biogénicas
/
Hipoxia Fetal
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Early Hum Dev
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Irlanda