Secretion of growth hormone releasing hormone in obese children.
J Endocrinol Invest
; 15(6): 453-7, 1992 Jun.
Article
en En
| MEDLINE
| ID: mdl-1401748
ABSTRACT
We have evaluated baseline and l-dopa-stimulated peripheral growth hormone releasing hormone (pGHRH) secretion in 6 obese pre-pubertal children and in 7 age-matched controls. Baseline pGHRH levels were no different between obese (36.6 +/- 9.8 pg/ml, mean +/- SE) and control children (40.6 +/- 10.1 pg/ml). Administration of l-dopa (500 mg po) caused a significant increase of pGHRH levels in both the obese (65.3 +/- 19.8 pg/ml, p less than 0.05) and the control children (84.1 +/- 10.0 pg/ml, p less than 0.003). Mean peak pGHRH levels after l-dopa were not significantly different between the two groups, whereas mean peak GH levels were significantly lower (p less than 0.05) in the obese (7.9 +/- 1.9 ng/ml) than in the control children (20.5 +/- 4.9 ng/ml). We conclude that despite reduced GH secretion, obese children have normal baseline and l-dopa stimulated pGHRH levels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Hormona del Crecimiento
/
Obesidad
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Endocrinol Invest
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia