Improvement of fog and exercise-induced bronchoconstriction after local and subcutaneous immunotherapy in mite asthma.
Allergol Immunopathol (Madr)
; 20(2): 61-6, 1992.
Article
en En
| MEDLINE
| ID: mdl-1442451
ABSTRACT
We compared the changes of non-specific bronchial hyperreactivity to methacholine, UNDW and exercise in 2 groups of patients with mite asthma treated with local immunotherapy (LIT group 12 patients) and subcutaneous immunotherapy (SIT group 8 patients) for 1 year. Bronchial challenges were done 1 week before the beginning and 1 week after the end of 1 year of treatment. The results showed a reduction of bronchial hyperreactivity to methacholine in the LIT group (PD 20FEV1 before 223 +/- 193, after 434 +/- 548) but not in the SIT group (PD 20FEV1 before 143 +/- 188, after 125 +/- 121) but the difference was not statistically significant. Exercise-induced bronchoconstriction completely disappeared in all the patients of LIT group (8/8) although only in 2 out of 4 patients of SIT group. Water-induced bronchoconstriction improved in 66% of LIT group (4/6) compared with none of SIT group (0/4). We conclude that, with the protocol of the present study, LIT is able to improve, more than SIT, non-specific bronchial hyperreactivity evaluated with osmotic stimuli as exercise and UNDW but not with pharmacologic stimuli as methacholine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Asma Inducida por Ejercicio
/
Tiempo (Meteorología)
/
Alérgenos
/
Desensibilización Inmunológica
/
Hiperreactividad Bronquial
/
Ácaros
Tipo de estudio:
Etiology_studies
/
Guideline
Límite:
Adolescent
/
Adult
/
Animals
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Allergol Immunopathol (Madr)
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
SG
/
SINGAPORE
/
SINGAPUR
/
SINGAPURA