Quantitation by gas chromatography with selected-ion monitoring mass spectrometry of "natural" diazepam, N-desmethyldiazepam and oxazepam in normal human serum.
J Chromatogr
; 579(1): 85-91, 1992 Aug 07.
Article
en En
| MEDLINE
| ID: mdl-1447353
ABSTRACT
During the past five years, the literature has tended to prove the occurrence of "natural benzodiazepines" in tissues and biological fluids of non-medicated humans. Several have been identified but very few papers deal with their quantitation in biological material. We present here a method for the specific and sensitive measurement of serum levels of diazepam, N-desmethyldiazepam and oxazepam by gas chromatography with selected-ion monitoring mass spectrometry in twenty human volunteers without medication. Diazepam was found over the whole population, in the range 7.3-32.0 pg/ml, identical in males and females. The other two were present in only some individuals (1.0-7.6 pg/ml for N-desmethyldiazepam and 2.0-13.0 pg/ml for oxazepam). The origin (endogenous, dietary or microbial) of these substances is still to be elucidated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazepam
/
Nordazepam
/
Diazepam
/
Cromatografía de Gases y Espectrometría de Masas
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Chromatogr
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia