Generation and characterization of IgG monoclonal antibodies specific for malondialdehyde.
Hybrid Hybridomics
; 22(4): 259-62, 2003 Aug.
Article
en En
| MEDLINE
| ID: mdl-14511571
ABSTRACT
Numerous studies have indicated that the oxidative modification of low-density lipoprotein (LDL) plays a critical role in the pathogenesis of atherosclerosis. Malondialdehyde-modified LDL (MDA-LDL) is one of the candidate oxidative products. Therefore, to allow the assessment of oxidized LDL in human serum, we developed monoclonal antibodies for MDA-LDL. Two of these-MDA1 and MDA2-bound to oxidized LDL but not to native LDL by Western blot analysis. The murine monoclonal antibodies to oxidized LDL have potential clinical implications, as imaging agents, for defining the compositions of atherosclerotic vessels in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Lipoproteínas LDL
/
Malondialdehído
/
Anticuerpos Monoclonales
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Hybrid Hybridomics
Año:
2003
Tipo del documento:
Article