Evolution of the yeast protein interaction network.
Proc Natl Acad Sci U S A
; 100(22): 12820-4, 2003 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-14557537
ABSTRACT
To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Genoma Fúngico
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Proteínas de Saccharomyces cerevisiae
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Bases de Datos Genéticas
/
Evolución Biológica
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos