Allylation of erythromycin derivatives: introduction of allyl substituents into highly hindered alcohols.
J Org Chem
; 68(23): 8847-52, 2003 Nov 14.
Article
en En
| MEDLINE
| ID: mdl-14604353
ABSTRACT
Functionalized erythromycin 9-oxime derivatives are 6-O-allylated under mild conditions using substituted allyl tert-butyl carbonates under palladium(0) catalysis. This allylation works well where traditional ether-forming protocols function poorly. Allyl tert-butyl carbonates provide higher yields in this reaction than lesser substituted carbonates such as ethyl or isopropyl. Aryl-substituted allyl carbonates or carbamates may be employed as well and, when used, produce trans-olefinic products.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Eritromicina
/
Alcoholes
Idioma:
En
Revista:
J Org Chem
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos