Differential changes in expression of a and b FGF, IGF-1 and -2, and TGF-alpha during seasonal growth and involution of roe deer testis.
Growth Factors
; 21(2): 95-102, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-14626357
ABSTRACT
Growth factors are involved in the regulation of testicular growth and involution of seasonal breeders. Therefore, we studied the seasonal expression of several growth factors in roe deer aFGF, bFGF, IGF-1, IGF-2, and TGF-alpha. Total RNA from testis tissue was extracted monthly and analyzed using quantitative RT-PCR. Localization of mRNAs was examined by in situ-hybridization. Levels of expression differed by more than three orders of magnitude. Expression also showed different seasonal patterns. IGF-1, IGF-2 and bFGF were maximally transcribed during testis recrudescence in spring. In contrast, the mRNA amount of aFGF reached its maximum between July (breeding season) and January. TGF-alpha mRNA-levels were very low and showed poor seasonal variation. Each growth factor showed its own typical expression localization in testicular tissues and cell types. The results suggest the specific role of different growth factors in the paracrine control of spermatogenesis and its seasonal regulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estaciones del Año
/
Testículo
/
Factor I del Crecimiento Similar a la Insulina
/
Factor II del Crecimiento Similar a la Insulina
/
Ciervos
/
Regulación de la Expresión Génica
/
Factor de Crecimiento Transformador alfa
/
Factores de Crecimiento de Fibroblastos
Límite:
Animals
Idioma:
En
Revista:
Growth Factors
Asunto de la revista:
BIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania