The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children.
Otolaryngol Head Neck Surg
; 129(6): 698-704, 2003 Dec.
Article
en En
| MEDLINE
| ID: mdl-14663438
ABSTRACT
OBJECTIVE:
To further evaluate the role of chromosomal translocation (15;19) in the presentation of the carcinoma (CA) of the upper aerodigestive tract. STUDY DESIGN ANDSETTING:
A retrospective study at a tertiary care pediatric medical center.RESULTS:
Seven patients with a mean age of 12 years presented with CA of nasopharynx (N = 2), sinonasal region (N = I), parotid gland (N = 2), or larynx (N = 2). Treatments included combinations of surgery (N = 5), chemotherapy (N = 5), and radiation therapy (N = 4). One patient with sinonasal CA and one patient with laryngeal CA had chromosomal translocation (15;19); these patients both died of their disease with a mean survival of 6 months. The 5 patients without translocation (15;19) responded well to treatment and are disease-free with a mean follow-up of 47 months.CONCLUSION:
The preliminary results appear to indicate poor prognosis associated with the presentation of chromosomal translocation (15;19) despite aggressive multi-modality treatment. Further investigation is needed to better understand the cause and relationship of the translocation (15;19) and aggressive behavior of these tumors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
Neoplasias de los Senos Paranasales
/
Neoplasias de la Parótida
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Neoplasias Nasofaríngeas
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos