Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells.
Metabolism
; 53(1): 84-8, 2004 Jan.
Article
en En
| MEDLINE
| ID: mdl-14681847
ABSTRACT
Ghrelin is a gastrointestinal peptide that stimulates food intake and growth hormone (GH) secretion. We studied the biosynthesis and secretion of ghrelin in a cancer cachexia mouse model. G361, a human melanoma cell line, was inoculated into nude mice. The body weight was reduced and the plasma concentration of interleukin-1beta (IL-1beta) was markedly higher in tumor-inoculated mice compared with vehicle-treated mice. Furthermore, white adipose tissue (WAT) weight, blood sugar level, and plasma concentrations of leptin and nonesterified fatty acids (NEFA) were significantly lower in tumor-inoculated mice. The plasma concentration of ghrelin increased with the progression of cachexia. The levels of both ghrelin peptide and mRNA in the stomach were also upregulated in tumor-inoculated mice. This study demonstrates that both ghrelin biosynthesis and secretion are stimulated in the long-term negative energy balance of tumor-inoculated cachectic mice. These findings suggest the involvement of ghrelin in the regulation of energy homeostasis in cancer cachexia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Caquexia
/
Regulación Neoplásica de la Expresión Génica
/
Hormonas Peptídicas
/
Melanoma
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Metabolism
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón