Impact of nitrate intake in drinking water on the thyroid gland activity in male rat.
Toxicol Lett
; 147(1): 27-33, 2004 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-14700525
ABSTRACT
The purpose of this study was to determine the effects of nitrate on both the activity of the thyroid gland and other biological parameters. After 5-month treatment, nitrate 150 and 500 mg/l induced a significant decrease in the serum level of thyroid hormone T3. For T4, the 500 mg/l dose only reduced its plasma level. On the other hand, nitrate induced a dose-dependent increase in the weight of the thyroid gland. The histological study of the thyroid gland shows vacuolisation and an increase in the size of the follicles accompanied by a flatness of follicular epithelium with nitrate 150 and 500 mg/l. We concluded that the presence of high concentrations of nitrate in drinking water influence the growth, induce morpho-functional modifications of the thyroid gland and might be considered as a goitrigenic factor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
/
Contaminantes del Agua
/
Compuestos de Potasio
/
Nitratos
Límite:
Animals
País/Región como asunto:
Africa
Idioma:
En
Revista:
Toxicol Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Marruecos