Fatal hemorrhage from androgen-related hepatic adenoma after hematopoietic cell transplantation.
J Pediatr Hematol Oncol
; 26(1): 16-8, 2004 Jan.
Article
en En
| MEDLINE
| ID: mdl-14707705
ABSTRACT
Fanconi anemia is a rare genetic disorder that leads to bone marrow failure. Hematopoietic cell transplantation (HCT) is currently the only treatment option with curative potential. When a suitable HLA-matched sibling donor is not available, patients are often treated with androgenic steroids before considering HCT. Such androgen treatments can lead to the development of hepatic adenomas, which usually regress upon stopping androgen therapy. A patient with Fanconi anemia is described who underwent an unrelated umbilical cord blood transplant with a history of a hepatic adenoma related to androgen therapy. No adenomas were detected on an ultrasound examination prior to HCT. Soon after HCT, he died due to sudden rupture and hemorrhage of a hepatic adenoma. This case illustrates the need for extra vigilance in the detection and management of hepatic adenomas in patients treated with androgens, especially prior to HCT.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre de Sangre del Cordón Umbilical
/
Anemia de Fanconi
/
Hemorragia
/
Andrógenos
/
Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos