Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry.
Bioorg Med Chem Lett
; 14(3): 695-9, 2004 Feb 09.
Article
en En
| MEDLINE
| ID: mdl-14741271
ABSTRACT
A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bencimidazoles
/
ARN Bacteriano
/
ARN Ribosómico 16S
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
