Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum.
Planta Med
; 69(12): 1130-5, 2003 Dec.
Article
en En
| MEDLINE
| ID: mdl-14750030
ABSTRACT
Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, and one new acid, caledonic acid 6 were isolated from the hexane-soluble extract of the stem bark of Calophyllum caledonicum. In the course of this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, isoapetalic acid 3, calolongic acid 4, apetalic acid 5 and isocalolongic acid 7 - were isolated. Their antifungal activity against the growth of the human pathogenic fungus Aspergillus fumigatus was then investigated. The results indicated that the crude extract, calolongic acid 4 and isocalolongic acid 7 exhibited strong inhibitory effects with MIC (80) values of 8, 4, 2 microg/mL, respectively. Besides, calolongic acid 4, its lactone derivative 4a and isocalolongic acid 7 markedly reduced the respiration of pea seed mitochondria.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromanos
/
Calophyllum
/
Transporte de Electrón
/
Fitoterapia
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
Planta Med
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia