[Renal dysfunction in workers exposed to arsenic and cadmium].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 21(6): 432-6, 2003 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-14761355
ABSTRACT
OBJECTIVE:
To examine the nephrotoxicity induced caused by combined effect of arsenic and cadmium in exposed workers.METHODS:
Urinary cadmium and arsenic were used as the exposure biomarkers of cadmium and arsenic. Urinary beta2-microglobulin (Ubeta2-MG), albumin (UALB) and N-acetyl-beta-D-glucosaminidase (UNAG) were measured as the effective biomarkers of tubular and glomerular dysfunction induced by cadmium and arsenic.RESULTS:
The combination of cadmium and arsenic induced more severe renal injury than that caused by either of the chemicals given alone. There were positive correlations and significant dose-effect among the concentrations of urinary cadmium, arsenic and levels of Ubeta2-MG, UALB, UNAG (P<0.05, P<0.01).CONCLUSION:
Cadmium combined with arsenic may have additive effect on renal dysfunction in workers exposed to arsenic and cadmium.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arsénico
/
Cadmio
/
Exposición Profesional
/
Riñón
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Asunto de la revista:
MEDICINA OCUPACIONAL
Año:
2003
Tipo del documento:
Article
País de afiliación:
China