Calcium regulating hormones after oral and intravenous calcium administration.
Eur J Clin Chem Clin Biochem
; 30(12): 815-22, 1992 Dec.
Article
en En
| MEDLINE
| ID: mdl-1489856
ABSTRACT
The aim of this study was to determine the changes in serum calcium concentration and in the concentrations of calcium regulating hormones after a single oral or intravenous calcium administration. Standard dosages of calcium, as used in routine patient care, were employed. Intact parathyrin, calcitonin, calcitriol, calcidiol, total calcium, ionized calcium, total protein and phosphate were determined in 12 healthy young men before and up to 8 h after oral and intravenous administration of calcium. During a fortnight there were four study days with 1000 mg calcium orally (p.o.), 2000 mg orally, 180 mg calcium intravenous (i.v.) and a control day without calcium. During the study the men were on a low calcium diet. We observed a sharp increase in the calcium concentration after i.v. administration (15 min total Ca + 0.48 +/- 0.32 mmol/l; ionized Ca + 0.25 +/- 0.15 mmol/l; p < 0.01). The concentration increase after the two oral loads was nearly identical. The maximal concentration of total calcium was reached after 120 min (1000 mg + 0.1 +/- 0.04 mmol/l; p < 0.001; 2000 mg + 0.12 +/- 0.04 mmol/l; p < 0.001). There was a significant increase in urinary calcium after all modes of calcium administration. Calcitonin increased significantly only after i.v. injection of calcium (+ 9.2 +/- 3.4 pmol/l; p < 0.001) while parathyrin decreased significantly after all modes of calcium administration (i.v. 15 min -1.9 +/- 0.88 pmol/l; p < 0.01; 1000 mg 90 min -0.78 +/- 0.75 pmol/l; p < 0.001; 2000 mg 90 min -1.02 +/- 0.57 pmol/l; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona Paratiroidea
/
Calcitonina
/
Calcio
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Chem Clin Biochem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA CLINICA
Año:
1992
Tipo del documento:
Article