The effects of activation and blockade of central P2X receptors on body temperature.
Neurosci Behav Physiol
; 33(9): 845-51, 2003 Nov.
Article
en En
| MEDLINE
| ID: mdl-14969421
ABSTRACT
The aim of the present work was to identify the role of ATP acting on specific P2X receptors in the central mechanisms of thermoregulation. Immunohistochemical studies demonstrated that brainstem structures involved in controlling body temperature contained large number of nerve cells bearing P2X ATP receptors. Experiments on conscious rats involving intracerebroventricular administration of an ATP analog and P2X antagonists showed that both activation and blockade of central P2X receptors produced marked changes in body temperature. Analysis of the effects of these substances provided grounds for suggesting that ATP acting on P2X receptors fulfils an important function in the mechanisms of transmitting afferent information from peripheral thermal receptors to thermoregulatory centers in the brainstem with responsibility for heat loss, while in pyrogen-induced fever ATP acting on these receptors may be involved in the activity of the endogenous antipyretic system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación de la Temperatura Corporal
/
Adenosina Trifosfato
/
Receptores Purinérgicos P2
Límite:
Animals
Idioma:
En
Revista:
Neurosci Behav Physiol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Belarús