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Nonswelling macroporous synbeads for improved efficiency of solid-phase biotransformations.
Basso, Alessandra; Braiuca, Paolo; De Martin, Luigi; Ebert, Cynthia; Gardossi, Lucia; Linda, Paolo; Verdelli, Silvia; Tam, Andrea.
Afiliación
  • Basso A; Dipartimento di Scienze Farmaceutiche, Università degli Studi, Piazzale Europa 1, 34127 Trieste, Italy.
Chemistry ; 10(4): 1007-13, 2004 Feb 20.
Article en En | MEDLINE | ID: mdl-14978827
An application of novel, highly porous nonswelling resins (Synbeads) for enzymatic catalysis on solid supports is reported. These new resins combine easy handling of the beads, chemical stability, improved accessibility of proteins and higher productivity relative to swelling polymers. The present study demonstrates that the resin porosity greatly affects the efficiency in solid-phase biotransformations and that Synbead resins are valuable alternatives to swelling polymers for solid-phase chemistry and biocatalysis. The present study investigates the influence of key parameters, such as porosity and reactive functional-group density, on the reaction efficiency.
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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania