Transfusion of plasma from a blood donor induced hepatitis E in Rhesus monkey.
Vox Sang
; 86(1): 45-7, 2004 Jan.
Article
en En
| MEDLINE
| ID: mdl-14984559
ABSTRACT
BACKGROUND AND OBJECTIVES:
Hepatitis E virus (HEV) infection is normally transmitted via the faeco-oral route. The possibility that the infection might be transmissible by blood has been suggested. Direct evidence of blood-borne transmission of hepatitis E infection is, however, absent. MATERIALS ANDMETHODS:
In this report, 10 ml of plasma obtained from a healthy, but hepatitis E viraemic, blood donor was transfused to a Rhesus monkey.RESULTS:
Acute hepatitis E developed following transfusion of blood from the hepatitis E viraemic donor. This was confirmed by virological, immunological, biochemical and histopathological data.CONCLUSIONS:
These results, combined with other epidemiological findings previously reported, indicate that transfusion-associated hepatitis E can occur. The risk of transfusion-associated HEV infection in endemic areas should be assessed and strategies developed to reduce it.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Donantes de Sangre
/
Hepatitis E
/
Reacción a la Transfusión
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vox Sang
Año:
2004
Tipo del documento:
Article
País de afiliación:
China