Dual inhibition of cyclooxygenase-1 and 5-lipoxygenase by aerial part of Bupleurum fruticescens methanol extract.
Fitoterapia
; 75(2): 179-86, 2004 Mar.
Article
en En
| MEDLINE
| ID: mdl-15030922
ABSTRACT
The effect of the methanol extract from aerial parts of Bupleurum fruticescens on the release of eicosanoids and hydrolytic enzymes was determined on in vitro cell systems. The extract had a significant effect on 5-lipoxygenase (5-LOX) activity, inhibiting both LTB4 and 5(S)-HETE production with IC50 values of 112 microg/ml and 95 microg/ml, respectively. At concentrations of 200 microg/ml, the extract also inhibited cyclooxygenase-1 (90%) and elastase activities (54%). The 12-LOX activity in intact platelets was not affected; a fact, which suggests that phospholipase A2 (PLA2) activity, is not modified by the extract.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Inhibidores de la Ciclooxigenasa
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Lipooxigenasa
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Elastasa de Leucocito
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Bupleurum
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Isoenzimas
/
Fitoterapia
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Fitoterapia
Año:
2004
Tipo del documento:
Article
País de afiliación:
España