Chronic immune complex disease: behavioral and immunological correlates.
J Neuropathol Exp Neurol
; 37(4): 426-36, 1978.
Article
en En
| MEDLINE
| ID: mdl-150457
ABSTRACT
Using a fear avoidance paradigm, behavioral effects were seen in Sprague-Dawley rats in which chronic immune complex disease was induced. These effects were related to changes in urine protein that developed during the course of the experiment. Experimental animals also had glomerular deposits of rat gamma globulin and BSA as determined by immunofluorescence; C3 deposits were observed in half of these animals. BSA and/or rat gamma-globulin, but not C3, was seen in the choroid plexus of half of the experimental animals. This is the first study to report behavioral changes associated with the induction of chronic immune complex disease in experimental animals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta
/
Enfermedades del Complejo Inmune
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Año:
1978
Tipo del documento:
Article