Werner syndrome protein--unwinding function to explain disease.
Sci Aging Knowledge Environ
; 2004(13): re3, 2004 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-15056797
ABSTRACT
Werner syndrome (WS) is one of three heritable human genetic instability/cancer predisposition syndromes that result from mutations in a member of the gene family encoding human RecQ helicases. Cellular defects are a prominent part of the WS phenotype. Here we review recent work to identify in vivo functions of the WS protein and discuss how loss of function leads to cellular defects. These new results provide clues to the origin of cell lineage-specific defects in WS patients and suggest a broader role for Werner protein function in determining disease risk in the general population.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Werner
/
ADN Helicasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Sci Aging Knowledge Environ
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos