Analysis of strychnine and brucine in postmortem specimens by RP-HPLC: a case report of fatal intoxication.
J Anal Toxicol
; 28(2): 141-4, 2004 Mar.
Article
en En
| MEDLINE
| ID: mdl-15068571
ABSTRACT
A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established. After solid-phase extraction using Oasis MCX cartridges the extracts were analyzed by high-performance liquid chromatography with diode-array detection. The limit of detection was 0.5 ng/mL blood for strychnine and brucine, and the limit of quantitation was 5 ng/mL blood for strychnine and brucine. The method was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L. Strychnine and brucine were detected in all the samples. The concentration in our case is consistent with that in previous reports.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Venenos
/
Semillas
/
Estricnina
/
Cromatografía Líquida de Alta Presión
/
Strychnos nux-vomica
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Anal Toxicol
Año:
2004
Tipo del documento:
Article
País de afiliación:
China