Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome.
Stroke
; 35(6): e153-5, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15073388
ABSTRACT
BACKGROUND:
It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.METHODS:
We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.RESULTS:
Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.CONCLUSIONS:
Elevated PP is associated with poor stroke outcome at 3 months.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Isquemia Encefálica
/
Accidente Cerebrovascular
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Stroke
Año:
2004
Tipo del documento:
Article
País de afiliación:
Reino Unido