Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination.
Cancer Lett
; 209(1): 111-8, 2004 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-15145526
ABSTRACT
The proteome of renal cell carcinoma and non-neoplastic kidney tissue was analysed from 12 patients by two-dimensional polyacrylamide gel electrophoresis to search for differentially expressed proteins in the tumour. Annexin IV was identified to be up-regulated in tumour cells. These patients and further 11 were characterized by RT-PCR. We found an increased amount of annexin IV mRNA. Immunohistochemical analysis revealed an altered localization of annexin IV in tumour cells. Additionally we demonstrate that over-expressed annexin IV promotes cell migration in a carcinoma model system. From these results above it seems possible that annexin IV plays an important role in the morphological diversification and dissemination of the clear cell renal cell carcinoma.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Renales
/
Anexina A4
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Adenocarcinoma de Células Claras
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Neoplasias Renales
Límite:
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania