Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery.
J Control Release
; 97(1): 125-32, 2004 May 31.
Article
en En
| MEDLINE
| ID: mdl-15147810
ABSTRACT
Mesoporous silica SBA-15 was prepared to evaluate its application as gentamicin drug delivery system. Two procedures were used to evaluate the delivery calcined powder and disk conformed. The samples were charged with gentamicin sulphate and the experiments were carried out in vitro. No significant difference between powder and disk was observed in the tests. The release profiles exhibited a pronounced initial burst release effect of 60%, followed by a very slow release pattern. A new HPLC method was employed for calculated gentamicin amount in the delivery test. This method requires a small amount of sample, very advisable in these kinds of assays.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gentamicinas
/
Sistemas de Liberación de Medicamentos
Idioma:
En
Revista:
J Control Release
Asunto de la revista:
FARMACOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
España