PrPSc accumulation in myocytes from sheep incubating natural scrapie.
Nat Med
; 10(6): 591-3, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15156203
ABSTRACT
Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrP(Sc) in a myocyte subset. In naturally infected sheep, PrP(Sc) is detectable in muscle several months before clinical disease onset. The relative amounts of PrP(Sc) suggest a 5,000-fold lower infectivity for muscle as compared to brain.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Scrapie
/
Proteínas PrPSc
/
Fibras Musculares Esqueléticas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia