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Morning or bedtime NPH insulin combined with sulfonylurea in treatment of NIDDM.
Groop, L C; Widén, E; Ekstrand, A; Saloranta, C; Franssila-Kallunki, A; Schalin-Jäntti, C; Eriksson, J G.
Afiliación
  • Groop LC; Fourth Department of Medicine, Helsinki University Hospital, Finland.
Diabetes Care ; 15(7): 831-4, 1992 Jul.
Article en En | MEDLINE | ID: mdl-1516500
OBJECTIVE: To compare the effect of morning and bedtime NPH insulin combined with daytime sulfonylurea on glycemic control in non-insulin-dependent diabetes mellitus (NIDDM) patients no longer responding to treatment with sulfonylureas alone. RESEARCH DESIGN AND METHODS: Twenty-four NIDDM patients who fulfilled these criteria were randomized to treatment with Protaphan human insulin in the morning or at bedtime (22 +/- 1 IU) plus 3.5 mg glibenclamide twice a day. RESULTS: Morning and bedtime NPH insulin resulted in equal reduction of HbA1 (from 13.5 +/- 0.3 to 9.4 +/- 0.1 and 9.6 +/- 0.2%, respectively) and mean self-monitored blood glucose (9.2 +/- 0.5 vs. 10.1 +/- 0.4 mM). Bedtime insulin resulted in lower morning blood glucose (7.8 +/- 0.5 vs. 9.1 +/- 0.4 mM; P less than 0.01), whereas morning insulin resulted in lower evening blood glucose (10.1 +/- 0.6 vs 12.1 +/- 0.6 mM, P less than 0.01). CONCLUSIONS: Morning and bedtime NPH insulin combined with glibenclamide are equipotent in the treatment of NIDDM patients with secondary failure to sulfonylurea. However, this treatment regimen normalizes blood glucose only in a small group of patients. Therefore, more intensified insulin therapy seems to be required to achieve this goal.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gliburida / Diabetes Mellitus Tipo 2 / Insulina Isófana Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Care Año: 1992 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gliburida / Diabetes Mellitus Tipo 2 / Insulina Isófana Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Care Año: 1992 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos