Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain.
FEBS Lett
; 567(1): 129-35, 2004 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-15165905
ABSTRACT
More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of extracellular matrix. In the neurons of the adult brain several components of the TIMP/MMP system are expressed and are responsive to changes in neuronal activity. Furthermore, functional studies, especially involving blocking of MMP activities, along with the identification of MMP substrates in the brain strongly suggest that this enzymatic system plays an important physiological role in adult brain neurons, possibly being pivotal for neuronal plasticity.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Inhibidores Tisulares de Metaloproteinasas
/
Metaloproteinasas de la Matriz
/
Inhibidores de la Metaloproteinasa de la Matriz
/
Neuronas
Límite:
Adult
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Polonia