Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways.
Inflamm Res
; 53(6): 230-8, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15167969
ABSTRACT
OBJECTIVE:
The aim of this study was to analyze a possible contribution of human neutrophil defensins and secretory leukocyte proteinase inhibitor (SLPI) to the induction of airway epithelial changes such as squamous cell metaplasia. MATERIALS ANDMETHODS:
The presence of these molecules and the number of proliferating (Ki-67-positive) epithelial cells was analyzed by immunohistochemistry in bronchial epithelium from subjects with (n = 15) or without (n = 14) chronic obstructive pulmonary disease (COPD).RESULTS:
Our data demonstrate higher numbers of defensin-positive (p = 0.0001), elastase-positive (p = 0.0001) and Ki-67-positive (p = 0.0001) cells in areas with squamous cell metaplasia as compared to areas with intact or damaged epithelium, while the reverse was observed for SLPI expression (p = 0.002). No differences were observed between subjects with or without COPD, nor between current smokers and those that had stopped smoking.CONCLUSIONS:
These data are in line with a role of defensins in the hyperproliferative phenotype of squamous metaplastic lesions in the airways. This role does not seem to be restricted to patients with COPD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bronquios
/
Carcinoma de Células Escamosas
/
Proteínas
/
Defensinas
/
Epitelio
/
Metaplasia
/
Neutrófilos
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND