A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cells.
Respirology
; 9(2): 286-8, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15182285
ABSTRACT
We describe a case of a patient with idiopathic pulmonary alveolar proteinosis (PAP), who had an elevated serum level of antigranulocyte-macrophage colony stimulating factor (anti-GM-CSF) antibody accompanied by T-cell receptor gene rearrangements in BAL fluid cells. Histopathological examination of the lung excluded lymphoma but revealed PAP and silicosis. There was no detectable serum anti-GM-CSF antibody in 50 outpatients with advanced silicosis who did not have PAP, suggesting that anti-GM-CSF antibody is directly linked to PAP but not to silicosis. We speculate that monoclonal expansion of a T-cell population may play a role in the production of anti-GM-CSF antibody and the development of PAP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteinosis Alveolar Pulmonar
/
Líquido del Lavado Bronquioalveolar
/
Reordenamiento Génico de Linfocito T
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Respirology
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón