Monozygotic twinning associated with day 5 embryo transfer in pregnancies conceived after IVF.
Hum Reprod
; 19(8): 1831-6, 2004 Aug.
Article
en En
| MEDLINE
| ID: mdl-15192064
ABSTRACT
BACKGROUND:
This study examines the association between day of embryo transfer and monozygotic (MZ) twinning.METHODS:
We used a population-based sample of 108,36 IVF/embryo transfer procedures in which the patients oocytes' were freshly fertilized (non-frozen; non-donor) and 39,98 resultant pregnancies from US clinics in 1999 and 2000. Cases were pregnancies for which the number of fetal hearts observed on ultrasound exceeded the number of embryos transferred. These pregnancies were considered to contain at least one set of MZ twins. A total of 226 MZ pregnancies were compared with two control groups 23,880 singleton pregnancies (one fetal heart) and 15,092 other multiple-gestation pregnancies (> or = 2 fetal hearts but the number of fetal hearts on ultrasound was less than or equal to the number of embryos transferred).RESULTS:
Cases of presumed MZ multiple-gestation pregnancies were more likely to have had a day 5 embryo transfer compared with day 3 embryo transfers than singleton pregnancies [adjusted odds ratio (AOR) = 3.92, 95% confidence interval (CI) = 2.97-5.17] or other multiple-gestation pregnancies (AOR = 3.91, 95% CI = 2.96-5.17) conceived with IVF/embryo transfer.CONCLUSIONS:
Day 5 embryo transfer may be associated with increased MZ twinning.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gemelos Monocigóticos
/
Fertilización In Vitro
/
Transferencia de Embrión
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hum Reprod
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos