Turning back the clock on neural progenitors.
Bioessays
; 26(7): 711-4, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15221852
Drosophila neural progenitor cells, or neuroblasts, alter their transcriptional profile over time to produce different neural cell types. A recent paper by Pearson and Doe shows that older neuroblasts can be reprogrammed to behave like young neuroblasts, and to produce early neural cell types, simply by expressing the transcription factor, Hunchback. The authors show that competence to respond to Hunchback diminishes over time. Manipulating neural progenitors in this way may have important implications for therapeutic uses of neural stem cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre
/
Factores de Transcripción
/
Proteínas de Drosophila
/
Proteínas de Unión al ADN
/
Drosophila melanogaster
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Bioessays
Asunto de la revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Año:
2004
Tipo del documento:
Article
Pais de publicación:
Estados Unidos