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Prevalence and risk of thrombophilia defects in vascular patients.
Vig, S; Chitolie, A; Sleight, S; Bevan, D; Dormandy, J; Thompson, M M; Halliday, A.
Afiliación
  • Vig S; Department of Vascular Surgery, St George's Hospital, Blackshaw Road, London SW17 0QT, UK.
Eur J Vasc Endovasc Surg ; 28(2): 124-31, 2004 Aug.
Article en En | MEDLINE | ID: mdl-15234691
This paper reviews the available data on the prevalence of thrombophilia defects in patients with peripheral vascular disease (PVD) and attempts to delineate the risk of failure of vascular intervention in these patients. The prevalence of thrombophilia in stable claudicants is 25% and increases to 40% in those requiring revascularisation, compared to only 11% in the control group. The overall prevalence of thrombophilia defects in patients with premature atherosclerosis appears to be between 15 and 30%. The prevalence in the typical cohort of patients with PVD appears to be similar. All these studies have recruited patients with symptoms significant enough to warrant intervention. The overall prevalence of thrombophilia calculated from these trials, therefore, may not be truly indicative of the general vascular population who may not even present primary or secondary healthcare. The risk of thrombotic occlusion following arterial revascularisation in patients with an identified thrombophilia defect appears to be almost three times that of patients with no evidence of a thrombophilia defect. The best management of these patients has not been determined and needs to be evaluated by prospective randomized trials.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Vasculares Periféricas / Trombofilia Tipo de estudio: Clinical_trials / Etiology_studies / Prevalence_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Eur J Vasc Endovasc Surg Asunto de la revista: ANGIOLOGIA Año: 2004 Tipo del documento: Article Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Vasculares Periféricas / Trombofilia Tipo de estudio: Clinical_trials / Etiology_studies / Prevalence_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Eur J Vasc Endovasc Surg Asunto de la revista: ANGIOLOGIA Año: 2004 Tipo del documento: Article Pais de publicación: Reino Unido