Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.

ABSTRACT

6-aralkylether- and 6-arylenol-ether-substituted nipecotic acids were synthesized. These analogues are poor GABA uptake inhibitors. The electronegative region concept developed in the N-substituted nipecotic acid series cannot be transferred on the side chain of this series of 6-substituted analogues.