Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.
Biochim Biophys Acta
; 1692(2-3): 121-44, 2004 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-15246683
ABSTRACT
The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Integrinas
/
Actinas
/
Familia-src Quinasas
/
Uniones Adherentes
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
2004
Tipo del documento:
Article