Mineralocorticoid receptor antagonists and hypertension: is there a rationale?
Curr Hypertens Rep
; 6(4): 279-87, 2004 Aug.
Article
en En
| MEDLINE
| ID: mdl-15257862
ABSTRACT
Accumulating evidence indicates that aldosterone is involved in cardiovascular disease by inducing inflammation in the presence of moderate amounts of salt in the diet. Spironolactone and eplerenone are the mineralocorticoid receptor (MR) antagonists currently available for the treatment of hypertension. They have similar safety and antihypertensive efficacy. The advantage of eplerenone is the lower incidence of anti-androgenic and progestational side effects. The rationale for using MR blockade in the treatment of hypertension is threefold the evidence of antihypertensive efficacy, the phenomenon of "aldosterone escape" occurring with angiotensin-converting enzyme inhibitor and angiotensin-receptor blockade therapy, and the compelling evidence that MR antagonism reduces target-organ damage in hypertensive patients and improves survival in patients with cardiovascular disease. Thus, blockade of the MR may be very useful in many patients with hypertension, particularly those at risk for or having evidence of target-organ damage.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espironolactona
/
Antagonistas de Receptores de Mineralocorticoides
/
Hipertensión
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Hypertens Rep
Asunto de la revista:
ANGIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos