Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.
Bioorg Med Chem Lett
; 14(16): 4161-4, 2004 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-15261262
ABSTRACT
Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications led to the identification of two optimized compounds, 14 and 16.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antitrombinas
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos