Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.

Santiago, Helton da Costa; Oliveira, Carolina Ferreira; Santiago, Luciana; Ferraz, Fernanda Oliveira; de Souza, Daniele da Glória; de-Freitas, Luiz Antônio Rodrigues; Afonso, Luís Carlos Crocco; Teixeira, Mauro Martins; Gazzinelli, Ricardo Tostes; Vieira, Leda Quercia

Santiago, Helton da Costa; Oliveira, Carolina Ferreira; Santiago, Luciana; Ferraz, Fernanda Oliveira; de Souza, Daniele da Glória; de-Freitas, Luiz Antônio Rodrigues; Afonso, Luís Carlos Crocco; Teixeira, Mauro Martins; Gazzinelli, Ricardo Tostes; Vieira, Leda Quercia.

Afiliación

Santiago HC; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.

Infect Immun ; 72(8): 4918-23, 2004 Aug.

Article en En | MEDLINE | ID: mdl-15271961

ABSTRACT

ABSTRACT

The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.

Asunto(s)

Quimiocina CCL5/metabolismo; Leishmania major; Leishmaniasis Cutánea/inmunología; Animales; Leishmaniasis Cutánea/parasitología; Leishmaniasis Cutánea/fisiopatología; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis Cutánea / Leishmania major / Quimiocina CCL5 Límite: Animals Idioma: En Revista: Infect Immun Año: 2004 Tipo del documento: Article País de afiliación: Brasil

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