[Tissue plasminogen activator, its inhibitor and other factors of the blood fibrinolytic system in stable coronary heart disease]. / Tkanevoi aktivator plazminogena, ego ingibitor i drugie faktory fibrinoliticheskoi cictemy krovi pri stabil'noi ishemicheskoi bolezni serdtsa.

The activity of tissue plasminogen activator (TPA), its rapid inhibitor (TPAL), C protein (Cp), plasminogen, alpha 2-antiplasmin, antithrombin III was evaluated and the levels of fibrinogen-fibrin degradation products and fibrinogen (F) were measured in 51 males with persistent coronary heart disease (CHD) and 16 without coronary atherosclerosis and atherosclerosis of other sites, which were matched for age and CHD risk factors. The patients were found to have elevated TRAI levels (17.3 +/- 1.2 IU/ml versus 12.2 +/- 2.2 IU/ml in the controls; p less than 0.05), increased TPA release (75.5 +/- 9.2 IU/ml versus 47.5 +/- 7.9 IU/ml in the controls; p less than 0.03) in response to venous occlusion, and lower Cp levels (-7.7 +/- 2.5%; p less than 0.01). The level of F correlated with the severity of coronary atherosclerosis. The patients with primary angina pectoris displayed higher TPA release than did those with chronic CHD. The presented facts are associated with overt changes occurring in the response of the endothelium in the patients, primarily, in early CHD.