Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia.
Neurology
; 63(3): 538-42, 2004 Aug 10.
Article
en En
| MEDLINE
| ID: mdl-15304590
ABSTRACT
Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas tau
/
Tauopatías
/
Demencia
/
Hipocampo
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos