Asymmetrically lesioned mesencephalon in healthy rodents: call for caution.
Brain Res
; 1022(1-2): 251-3, 2004 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-15353237
ABSTRACT
Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy--commercially available--mice and rats, although both the number of Nissl-stained cells and the striatal dopaminergic innervation are unaffected. This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tirosina 3-Monooxigenasa
/
Mesencéfalo
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia