Synthetic molecules as antibody replacements.
Acc Chem Res
; 37(9): 711-8, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15379586
ABSTRACT
Antibodies are by far the most versatile, valuable, and widely used protein-binding agents. They are essential tools in biological research and are increasingly being developed as therapeutic reagents. However, antibodies have a number of practical limitations, and it would be desirable in many applications to replace them with simpler, more robust synthetic molecules. Unfortunately, synthetic protein-binding agents rarely exhibit the high affinity and specificity typical of a good antibody. This article reviews efforts to overcome these limitations and to develop a facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Biespecíficos
/
Materiales Biomiméticos
Idioma:
En
Revista:
Acc Chem Res
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos