Adaptive doses of irradiation-an approach to a new therapy concept for bladder cancer?
Radiat Environ Biophys
; 43(4): 271-6, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15455244
ABSTRACT
Radiation adaptive response in terms of induced radioresistance or hyperradiosensitivity, has been studied in HCV29 (human bladder epithelium) and RT4 (human bladder carcinoma) cell lines. After pre-irradiation doses of 0.05 Gy or 0.1 Gy, HCV29 cells showed induced radioresistance, whereas after pre-irradiation doses of 0.05 Gy, 0.1 Gy, 0.2 Gy, and 0.5 Gy, the RT4 cells clearly showed hyperradiosensitivity. On the basis of these results, an approach has been developed that may lead to a concept for a new radiotherapeutic regimen of bladder cancer that includes protection of normal cells, on the one hand, and the potential of tumor cell damage, on the other hand. These findings need to be confirmed in further studies for the benefit of the patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tolerancia a Radiación
/
Neoplasias de la Vejiga Urinaria
/
Adaptación Fisiológica
/
Supervivencia Celular
/
Urotelio
Límite:
Humans
Idioma:
En
Revista:
Radiat Environ Biophys
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania