Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine?
Allergy
; 59(11): 1219-23, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15461605
ABSTRACT
Chemokines are a superfamily of small cytokines with activities ranging from leukocyte traffick to hematopoiesis, angiogenesis, and tissue organogenesis. Secondary lymphoid-organ chemokine (SLC/CCL21) was originally reported as a chemokine constitutively expressed by stromal cells and high endothelial venules in secondary lymphoid tissues and endothelium of afferent lymphatics, directing CCR7+ cells. More recently, others and we have demonstrated that SLC/CCL21 is up-regulated in different skin inflammatory conditions. Thereafter, this molecule is much more than a constitutive chemokine, which could play a role in effector and regulatory immune functions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quimiocinas CC
/
Tejido Linfoide
Límite:
Humans
Idioma:
En
Revista:
Allergy
Año:
2004
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
DENMARK
/
DINAMARCA
/
DK