Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine.
Chem Commun (Camb)
; (20): 2324-5, 2004 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-15490002
ABSTRACT
The one-pot three-component addition reaction of trimethylsilylacetylene, aldehydes and dibenzylamine provides in the presence of CuBr/Quinap as catalyst, various enantiomerically enriched propargylamines in good yields (up to 99%) and excellent enantiomeric excess (up to 98%ee) which can be used as a key intermediate in the synthesis of the alkaloid (S)-(+)-coniine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania