Dexamethasone decreases neurological sequelae and caspase activity.
Intensive Care Med
; 31(1): 146-50, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15502933
ABSTRACT
OBJECTIVE:
To evaluate the use of dexamethasone in a model of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables.DESIGN:
Randomized, prospective animal study.SETTING:
University research laboratory.SUBJECTS:
Male Wistar rats.INTERVENTIONS:
Animals underwent a basilar cistern injection of either placebo or a suspension of Group B Streptococcus. Sixteen hours after inoculation, animals were randomized and received either dexamethasone or placebo in addition to antibiotics. Neurobehavioral performance and biological markers of brain injury were assessed at 3 days and 9 days after randomization. In a second experiment, caspase 1 and 3 were evaluated at 6 h, 24 h, and 72 h after dexamethasone administration. MEASUREMENTS AND MAINRESULTS:
Neurobehavioral performance at 3 days and 9 days was significantly improved in the dexamethasone group. Serum C-tau and cerebral edema were decreased after 3 days of dexamethasone treatment. Dexamethasone decreased Caspase 3 activation in meningitic animals.CONCLUSION:
These findings demonstrate that dexamethasone decreases acute brain injury in a rat model of bacterial meningitis as measured by preservation of neurobehavioral performance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estreptocócicas
/
Lesiones Encefálicas
/
Dexametasona
/
Meningitis Bacterianas
/
Caspasas
/
Actividad Motora
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Intensive Care Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos