Enantioselective synthesis of allenyl carbinols by the CBS reduction in nitroethane: dramatic solvent effect for reactivity and enantioselectivity.

ABSTRACT

Dramatic solvent effect of nitroethane was observed in the catalytic asymmetric reductions of allenyl ketones and alpha,beta-ynones using the oxazaborolidine cayalyst to yield the corresponding alcohols in high levels of enantioselectivity.