The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.
Bioorg Med Chem Lett
; 14(24): 6107-11, 2004 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-15546739
ABSTRACT
A novel series of [2.2.1]-azahydantoins has been designed and synthesized in an enantiospecific manner. The ability of these compounds to act as antagonists to the androgen receptor was investigated and several were found to have potent activity in vitro.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Aza
/
Antagonistas de Receptores Androgénicos
/
Hidantoínas
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
